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Saturday, April 25, 2020 | History

6 edition of Quadruplex nucleic acids found in the catalog.

Quadruplex nucleic acids

Quadruplex nucleic acids

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Published by RSC Pub. in Cambridge .
Written in English

    Subjects:
  • Quadruplex nucleic acids

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Stephen Neidle, Shankar Balasubramanian.
    SeriesRSC biomolecular sciences
    ContributionsNeidle, Stephen., Balasubramanian, Shankar.
    Classifications
    LC ClassificationsQP625.Q33 +
    The Physical Object
    Paginationxiv, 301 p. :
    Number of Pages301
    ID Numbers
    Open LibraryOL17164608M
    ISBN 100854043748
    LC Control Number2007367383

    solution NMR spectroscopy as applied to quadruplex nucleic acids. 2. The identification of a quadruplex Once a nucleic acid sequence has been identified with potential to fold into a quadruplex, the sequence is typi-cally synthesized using solid phase methods, e.g., using b-cyanoethyl phosphoramidite chemistry, and purified by reversed-phase File Size: KB.


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Quadruplex nucleic acids Download PDF EPUB FB2

Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and : $ The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids.

This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular by: Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and stability.

The biology of quadruplexes and G-rich genomic regions and G-quartets in supramolecular chemistry and nanoscience are also considered. About this book. About this book. This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application.

The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Visualizing the Quadruplex: From Fluorescent Ligands to Light-Up Probes, by Eric Largy, Anton Granzhan, Florian Hamon, Daniela Verga and Marie-Paule Teulade-Fichou.- Calculation of Hydrodynamic Properties for G-Quadruplex Nucleic Acid Structures from in silico Bead Models, by Huy T.

Le, Robert Buscaglia, William L. Dean, Jonathan B. Chaires and. Quadruplexes are structures containing as their basis typically 3–4 G–quartets linked together, and can be either discrete entities formed by short sequences or embedded within a longer nucleic acid sequence.

Select 2 - DNA and RNA Quadruplex Structures. Book chapter Full text access. Quadruplex Nucleic Acids | Stephen Neidle, Shankar Balasubramanian | download | B–OK.

Download books for free. Find books. Calculation of Hydrodynamic Properties for G-Quadruplex Nucleic Acid Structures from in silico Bead Models, by Huy T.

Le, Robert Buscaglia, William L. Dean, Jonathan B. Chaires and John O. Trent.- Energetics of Ligand Binding to G-Quadruplexes, Concetta Giancola and Bruno Pagano From the book: Quadruplex Nucleic Acids Fundamentals of Quadruplex Structures From the book series: RSC Biomolecular Sciences.

; Journals, books & databases; Home; About us; Membership & professional community; Campaigning & outreach; Journals, books & databases; Teaching & learning;Cited by: Introduction.

This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application.

The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. The Hardcover of the Quadruplex Nucleic Acids by Jonathan B. Chaires at Barnes & Noble. FREE Shipping on $35 or more. Get FREE SHIPPING on Orders of $35+ Customer information on COVID B&N Outlet Membership Educators Gift Cards Stores & Events HelpPages: The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids.

This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular effects. G-Quadruplex Nucleic Acids: Methods and Protocols (1st ed.

) (Methods in Molecular Biology #) The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Practical and cutting-edge, G-Quadruplex DNA: Methods and Protocols is a valuable resource for both novice and.

Buy Quadruplex Nucleic Acids Books online at best prices in India by Jonathan B. Chaires,David Graves,Jonathan B Chaires from Buy Quadruplex Nucleic Acids online of India’s Largest Online Book Store, Only Genuine Products.

Lowest price and Replacement Guarantee. Cash On Delivery Available. A free online book on the chemistry and biology of nucleic acids, written by Prof.

Tom Brown and Dr Tom Brown (Jnr). The book is ideal for chemistry and biology students and also provides practical information for researchers working in the lab. Nucleic acid structure. Transcription, Translation and Replication. Mutagenesis and DNA g: Quadruplex. Visualizing the Quadruplex: From Fluorescent Ligands to Light-Up Probes, by Eric Largy, Anton Granzhan, Florian Hamon, Daniela Verga and Marie-Paule Teulade-Fichou.- Calculation of Hydrodynamic Properties for G-Quadruplex Nucleic Acid Structures from in silico Bead Models, by Huy T.

Le, Robert Buscaglia, William L. Dean, Jonathan B. Chaires and Brand: Springer Berlin Heidelberg. Quadruplex Nucleic Acids by David M. Lilley,available at Book Depository with free delivery : David M. Lilley. These G-quadruplex structures have been found to form in nucleic acid regions of biological significance, including human telomeres, gene promoters, and untranslated regions of Author: Stephen Neidle.

Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding.

Open Library is an open, editable library catalog, building towards a web page for every book ever published.

Quadruplex Nucleic Acids by Jonathan B. Chaires, David Graves,Springer edition, paperback. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

Open Library is an open, editable library catalog, building towards a web page for every book ever published. Quadruplex Nucleic Acids by Jonathan B.

Chaires, David. Quadruplex nucleic acids — helical four-stranded structures known to form from guanine-rich nucleic acid sequences through Hoogsteen-type hydrogen bonding — were once just laboratory : Stephen Neidle. Quadruplex Nucleic Acids as Novel Therapeutic Targets.

Neidle S(1). Author information: (1)UCL School of Pharmacy, University College London, Brunswick Square, London WC1N 1AX, U.K. Quadruplex-forming sequences are widely prevalent in human and other genomes, including bacterial by: Nucleic Acids Research18 DOI: /nar/gkz Emilia Puig Lombardi, Arturo Londoño-Vallejo.

A guide to computational methods for G-quadruplex prediction. Nucleic Acids Research48 (1), DOI: /nar/gkzCited by: A distinguishing feature of this minireview is the strong emphasis on helicases that resolve G-quadruplex nucleic acids.

Existence of sequences predicted to form G4 structures in the human genome Using algorithms to predict the probability of DNA sequences to form G-quadruplex structures, it has been estimated that there are over Cited by: DNA oligonucleotides that have repetitive tracts of guanine bases can form G‐quadruplex structures that display an amazing polymorphism.

Structures of several new G‐quadruplexes have been solved rece Cited by: Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies.

It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and Brand: Elsevier Science.

Probing ligand and cation binding sites in G-quadruplex nucleic acids by mass spectrometry and electron photodetachment dissociation sequencing.

The Analyst34 DOI: /C9ANC. Marta Dudek, Marco Deiana, Ziemowit Pokladek, Krzysztof Pawlik, Katarzyna by: Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and stability.

INTRODUCTION. The inherent propensity of guanines to self-associate forming four-stranded helical structures has been known since the early s ().Subsequently it was demonstrated that the conserved DNA sequence repeats of telomeres form G-quadruplex (or G4) structures in vitro (2,3).Since then numerous biochemical and structural analyses have established that nucleic acid Cited by: In molecular biology, G-quadruplex secondary structures (G4) are formed in nucleic acids by sequences that are rich in guanine.

They are helical in shape and contain guanine tetrads that can form from one, two or four strands. The unimolecular forms often occur naturally near the ends of the chromosomes, better known as the telomeric regions, and in transcriptional regulatory regions of. Quadruplex Nucleic Acids | Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood.

Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. G-quadruplex (G4) is a non-canonical four-stranded nucleic acid structure and the RHAU helicase has been identified to have high specificity for recognition of parallel-stranded G4s.

We have designed and synthesized two stapled peptide analogues of the G4-specfic motif. with nucleic acids using novel strategies is a significant consideration in research. According to this, finding anti-tumor agents that target the G-quadruplex structure in nucleic acids has been raised as an alternative drug development strategy, since it might increase the selectivity and specificity of drugs on certain genome by: 4.

A guide to computational methods for G-quadruplex. prediction. Emilia Puig Lombardi, Arturo Londoňo-Vallejo. Nucleic Acids Research, gkz ElTetrado - a new tool that identifies and annotates tetrads and quadruplexes in the 3D structures of nucleic. acids. Zok, T., Popenda, M.

& Szachniuk Intercalation of a Heterocyclic Ligand between. G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome.

G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or other cancer-related genes.

Therefore, targeting G-quadruplexes has become a novel promising anti-tumor by: 4. 1 Introduction: G-Quadruplex nucleic acids G-quadruplexes (G4) encompass guanine-rich nucleic acids that fold by forming successive quartets of guanines (also called G-tetrads), stabilized by intra-quartet hydrogen bonds (Fig.

1A), inter-quartet stacking, Cited by: Book: 'Quadruplex Nucleic Acids' I just received the book Quadruplex Nucleic Acids yesterday and I must say that it's a great book. Anyone interested in getting a broad overview of almost everything related to G-quadruplexes will find this book useful.

It covers everything from structure, energetics, dynamics and biological function to ligand. is a platform for academics to share research papers. The versatile DNA G-quadruplex structure has emerged as an interesting alternative reporter system applied in different biosensor platforms.

In comparison to the conventional reporter systems like enzymatic or fluorescent, DNA G-quadruplex has some distinct advantages, as it is thermostable, easy to produce, low cost and most importantly able to be by: 1.The 4th International Meeting on Quadruplex Nucleic Acids will be held at the Nanyang Technological University, Singapore, on JulyThe International Meetings on Quadruplex Nucleic Acids, organized bi-annually sinceare the major conference series in the field of G-quadruplexes and guanosine self-assembly.

The meeting will feature a large program of lectures from world-renowned.Guanine quadruplexes (G4s) are four-stranded secondary structures of nucleic acids which are stabilized by noncanonical hydrogen bonding systems between the nitrogenous bases as well as extensive base stacking, or pi-pi, interactions.

Formation of these structures in either genomic DNA or cellular RNA has the potential to affect cell biology in many facets including telomere maintenance Cited by: